Bicyclic isothiourea derivatives useful in therapy

Details Bicyclic isothiourea derivatives useful in therapy Bicyclic isothiourea derivatives useful in therapy

C - Chemistry, Metallurgy

07

D

C07D 217/22 (2006.01) A61K 31/155 (2006.01) A61K 31/275 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/535 (2006.01) C07C 335/32 (2006.01) C07D 217/04 (2006.01)

Patent

CA 2211299

There are provided novel compounds of formula (I) wherein D represents alkyl C1 to 6; T represents a C3-5 saturated or unsaturated alkylene chain substituted by -(CH2)m-NXY; -O-(CH2)2-NH- substituted by -(CH2)m-NXY; or -U- (CH2)a-N(X)-(CH2)b-; and a, b, m, X and Y are as defined in the specification together with processes for their preparation, compositions containing them and their use in therapy. Compounds of formula (I) are expected to be useful inter alia in the treatment of neurodegenerative disorders.

Des composés nouveaux ont la formule (I), dans laquelle D désigne alkyle C¿1?-C¿6?; T désigne une chaîne alkylène saturée ou insaturée C¿3-5? substituée par -(CH¿2?)¿m?-NXY, -O-(CH¿2?)¿2?-NH- substitué par -(CH¿2?)¿m?-NXY; ou -U-(CH¿2?)¿a?-N(X)-(CH¿2?)¿b?-; et a, b, m, X et Y ont la signification donnée dans la description. L'invention concerne également des procédés de préparation de ces composés, des compositions qui les contiennent et leur utilisation en thérapie. Les composés ayant la formule (I) sont supposés utiles pour traiter entre autres des troubles neurodégénératifs.

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