System for osmotic delivery of pharmaceutically active agents

Details System for osmotic delivery of pharmaceutically active agents System for osmotic delivery of pharmaceutically active agents

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61K 9/30 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01)

Patent

CA 2446712

An osmotic system for delivering a pharmaceutically active agent which comprises a core portion, a layer portion enclosing the core portion, and a semipermeable wall portion enclosing the core portion and the layer portion. The core portion includes the pharmaceutically active agent at a first concentration. The pharmaceutically active agent is present in the layer portion at a second concentration. The second concentration is greater than the first concentration. Such a system provides for the osmotic release of the pharmaceutically active agent in release profile other than a zero order release profile, and wherein the release profile is similar to or approaches or reaches a first order release profile.

L'invention concerne un système osmotique d'administration d'un agent pharmaceutiquement actif comprenant une partie de coeur, une partie de couche renfermant la partie de coeur ainsi qu'une partie de paroi semi-perméable renfermant la partie de coeur et la partie de couche. La partie de coeur comprend l'agent pharmaceutiquement actif à une première concentration. L'agent pharmaceutiquement actif est présent dans la partie de couche à une seconde concentration. La seconde concentration est supérieure à la première concentration. Ce système permet la libération osmotique de l'agent pharmaceutiquement actif en un profil de libération autre qu'un profil de libération d'ordre zéro et le profil de libération est similaire à, tend à ou atteint un profil de libération de premier ordre.

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