Oros push-stick for controlled delivery of active agents

A - Human Necessities – 61 – K

Patent

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A61K 9/00 (2006.01) A61K 9/24 (2006.01) A61K 9/36 (2006.01)

Patent

CA 2540047

A sustained release dosage form is provided comprising a pharmaceutically active agent and pharmaceutically acceptable salts thereof and adapted to release as an erodible solid over a prolonged period of time, wherein the dosage form provides burst release of the pharmaceutically active agent without the use of an immediate release drug coating. The dosage form is able to deliver high doses of poorly soluble or slowly dissolving active agents at a controlled rate. Methods of using the dosage forms to treat disease or conditions in human patients are also disclosed.

L'invention concerne une forme posologique à libération prolongée comprenant un agent pharmaceutiquement actif et ses sels pharmaceutiquement acceptables, cette forme posologique étant conçue sous forme de solide à libération par érosion sur une période prolongée, la libération par décharge de l'agent pharmaceutiquement actif ne nécessitant pas l'utilisation d'un enrobage de médicament à libération immédiate. Ladite forme posologique peut libérer des doses élevées d'agents actifs peu solubles ou à dissolution lente à vitesse contrôlée. La présente invention porte également sur des méthodes d'utilisation de ces formes posologiques pour traiter des maladies et des états chez des humains.

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