Method of predicting survival of a non-small-cell lung...

Details Method of predicting survival of a non-small-cell lung... Method of predicting survival of a non-small-cell lung...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/337 (2006.01)

Patent

CA 2647579

Method for predicting the survival of a patient suffering from NSCLC to an antimicrotubule agent based chemotherapy treatment which comprises the step of determining the methylation state of a nucleic acid encoding CHFR in a biological sample from the patient, wherein the presence of methylation is indicative of longer survival of said patient as a response to said chemotherapy treatment. The methylation status of the CHFR gene can be easily determined in a serum sample.

L'invention concerne une méthode pour prédire la survie d'un patient souffrant d'un NSCLC à un traitement par chimiothérapie à base d'un agent anti-microtubule, qui consiste à déterminer l'état de méthylation d'un acide nucléique codant CHFR dans un échantillon biologique dudit patient, la présence d'une méthylation étant indicatrice d'une survie plus longue dudit patient, en réponse à ce traitement par chimiothérapie. L'état de méthylation du gène CHFR peut être facilement déterminé dans un échantillon de sérum.

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