Materials and methods for treating hypercholesterolemia

Details Materials and methods for treating hypercholesterolemia Materials and methods for treating hypercholesterolemia

C - Chemistry, Metallurgy

07

C

C07C 69/675 (2006.01) A61K 31/47 (2006.01) A61K 31/505 (2006.01) A61P 3/06 (2006.01) C07C 69/708 (2006.01) C07C 69/732 (2006.01) C07D 207/34 (2006.01) C07D 209/10 (2006.01) C07D 209/12 (2006.01) C07D 209/24 (2006.01) C07D 213/30 (2006.01) C07D 213/55 (2006.01) C07D 213/80 (2006.01) C07D 215/14 (2006.01) C07D 239/42 (2006.01) C07D 307/80 (2006.01) C07D 311/72 (2006.01)

Patent

CA 2492906

The subject invention provides novel HMG-CoA-reductase inhibitors. In a preferred embodiment, the HMG-CoA reductase inhibitors of the subject invention can be deactivated to a primary inactive metabolite by hydrolytic enzymes. Compounds of the present invention can be advantageously used to treat patients suffering hypercholesterolemia.

La présente invention concerne de nouveaux inhibiteurs de L'HMG-CoA réductase. Dans un mode préféré de l'invention, les inhibiteurs de l'HMG-CoA réductase présentés peuvent être désactivés en un métabolite inactif primaire par des enzymes hydrolytiques. Les composés selon la présente invention peuvent être utilisés de façon avantageuse pour traiter des patients souffrant d'hypercholestérolémie.

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