Acetylenes disubstituted with a phenyl group and a...

Details Acetylenes disubstituted with a phenyl group and a... Acetylenes disubstituted with a phenyl group and a...

C - Chemistry, Metallurgy

07

D

167/207, 260/328

C07D 311/58 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/47 (2006.01) C07D 215/14 (2006.01) C07D 335/06 (2006.01)

Patent

CA 2023813

ACETYLENES DISULSTITUTED WITH A PHENYL GROUP AND A 2- SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4 - TETRAHYDROQUI- NOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY Abstract of the Disclosure Retinold-like activity is exhibited by compounds of the formula Image where X is S, O or NR'; where R' is hydrogen or lower alkyl: R1, R2 and R3 are hydrogen or lower alkyl; R4 and R5 are hydrogen or lower alkyl with the proviso that R4 and R5 cannot both be hydrogen, R6 is hydrogen, lower alkyl, lower alkenyl, lower cycloalkyl or halogen; n is 0 - 5, and B is H, -COOH or a pharmaceutically acceptable salt, ester or amide thereof, -CH2OH or an ether or ester derivative, or -CHO or an acetal derivative, or -COR1 or a ketal derivative where R1 is -(CH2)mCH3 where m is 0-4, or a pharmaceutically acceptable salt thereof.

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