A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/536 (2006.01) A61K 9/48 (2006.01) A61K 31/535 (2006.01) A61K 47/36 (2006.01)
Patent
CA 2321523
The present invention provides improved oral dosage form formulations of efavirenz that are useful in the inhibition of human immunodeficiency virus (HIV), the prevention or treatment of infection by HIV, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS). In particular, the present invention relates to compressed tablets or capsules comprising efavirenz that contain one or more disintegrants that enhance the dissolution rate of the efavirenz in the gastrointestinal tract thereby improving the rate and extent of absorption of efavirenz in the body. The present invention also relates to the process of making such tablets or capsules.
La présente invention concerne des préparations améliorées d'une forme posologique orale d'efavirenz, utiles pour l'inhibition du virus de l'immunodéficience humaine (VIH), la prévention ou le traitement de l'infection à VIH, et le traitement du syndrome d'immunodéficience acquise (SIDA). L'invention concerne en particulier des tablettes comprimées ou des capsules d'efavirenz contenant un ou plusieurs désintégrants capables d'augmenter la vitesse de dissolution de l'efavirenz dans le tube digestif, en améliorant ainsi la vitesse et l'efficacité d'absorption de l'efavirenz dans le corps. L'invention concerne en outre le procédé de production desdits comprimés ou capsules.
Buehler John D.
Landmann Brian R.
Makooi-Morehead William T.
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
Du Pont Pharmaceuticals Company
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