Novel amide derivative and use thereof as medicine

Details Novel amide derivative and use thereof as medicine Novel amide derivative and use thereof as medicine

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/551 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07D 263/22 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2741661

Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide derivative represented by the following formula (I) (see formula I) wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof.

La présente invention concerne un nouveau composé de faible poids moléculaire qui inhibe la production de MMP inductibles, en particulier la MMP-9, plutôt que la production de la MMP-2 constitutive, ainsi quun agent de prévention/thérapeutique dune maladie auto-immune ou de lostéo-arthrite. Linvention concerne en outre un dérivé amide représenté par la formule (I) (dans laquelle les symboles respectifs sont tels que définis dans la description), un sel pharmacologiquement acceptable de celui-ci, ou un hydrate ou un solvate de celui-ci.

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