A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/485 (2006.01)
Patent
CA 2411564
Inflammatory or neuropathic pain in both men and women patients is treated by administering, sequentially or simultaneously, (a) nalbuphine and (b) an opioid antagonist selected from naloxone, naltrexone and nalmefene, or a salt or prodrug of nalbuphine and/or the opioid antagonist. Preferably, administration is made of (a) an amount of from about 3 to about 8 mg nalbuphine and (b) from about 0.2 to about 0.8 mg of an opioid antagonist selected from naloxone, naltrexone and nalmefene, or a salt and/or prodrug of either (in an amount that produces in a patient the same blood concentration of the compound in question as would administration of said amount of the nalbuphine or opioid antagonist itself).Treatment of both inflammatory and neuropathic pain can be achieved; side effects common with µ-opioids such as morphine were not observed.
Selon cette invention, il est possible de traiter la douleur inflammatoire ou neuropathique chez les hommes et les femmes en administrant, séquentiellement ou simultanément, (a) la nalbuphine et (b) un antagoniste opioïde sélectionné parmi naloxone, naltrexone et nalmefène, ou un sel ou promédicament de la nalbuphine et/ou de l'antagoniste opioïde. De préférence, la substance administrée comprend (a) d'environ 3 à environ 8 mg de nalbuphine et (b) d'environ 0,2 à environ 0,8 mg d'un antagoniste opioïde sélectionné parmi naloxone, naltrexone et nalmefène, ou un sel et/ou promédicament de l'un ou l'autre (dans une quantité qui produit dans le corps du patient la même concentration sanguine du composé précité que si on administrait la quantité de nalbuphine ou de l'antagoniste opioïde seul). Ce traitement de la douleur inflammatoire et neuropathique a pu être réalisé sans noter d'effets secondaires communs aux opioïdes µ tels que la morphine.
Fetherstonhaugh & Co.
The Regents Of The University Of California
LandOfFree
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