Liponucleotide compounds

Details Liponucleotide compounds Liponucleotide compounds

C - Chemistry, Metallurgy

07

H

C07H 19/207 (2006.01) A61K 31/70 (2006.01) C07H 19/14 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2137176

The present invention relates to new liponucleotide analog compounds having useful antiviral activity, represented by general formula (I) : (see formula I) wherein R1 is a saturated or unsaturated alkyl having 6-22 C atoms ; R2 is a saturated or unsaturated alkyl having 12 - 20 C atoms ; R3 and R4 are each hydrogen or hydroxy ; and B is one of the nucleoside bases of formula (a): (see formula II) wherein R5 is a hydrogen, halogen, hydroxy, amino, mercapto, or C1 - C4 alkyl amino ; R6 is a hydrogen, halogen or amino ; W is a nitrogen or C - R8 where R8 is hydrogen, halogen, amino or C1 - C4 alkyl, and pharmaceutically acceptable salts thereof.

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