C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/33 (2006.01) A61K 31/404 (2006.01) A61P 19/00 (2006.01) C07D 209/00 (2006.01) C07D 209/08 (2006.01) C07D 213/81 (2006.01) C07D 215/40 (2006.01) C07D 215/48 (2006.01) C07D 215/54 (2006.01) C07D 215/60 (2006.01) C07D 217/02 (2006.01) C07D 221/00 (2006.01) C07D 231/38 (2006.01) C07D 231/56 (2006.01) C07D 235/00 (2006.01) C07D 241/44 (2006.01) C07D 277/00 (2006.01) C07D 277/62 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 471/04 (2006.01) C07D 513
Patent
CA 2467435
The present invention relates to compounds of formula (I) wherein Rl, R2, R3, R4, R5, R6 and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment of diseases which are associated with cysteine proteases such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.
L'invention se rapporte à des composés représentés par la formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ et n sont tels que définis dans la description et les revendications et sur des sels pharmaceutiquement acceptables et/ou des esters pharmaceutiquement acceptables de ces derniers. Les composés sont utiles dans le traitement de maladies associées aux cystéines protéases telles que l'ostéoporose, l'oséoarthrite, l'arthrite rhumatoïde, la métastase tumorale, la glomérulonéphrite, l'athérosclérose, l'infarctus du myocarde, l'angine de poitrine, l'angine de poitrine instable, l'attaque cardiaque, la rupture de plaques, les attaques ischémiques transitoires, l'amaurose transitoire, les maladies artérielles oblitérantes périphériques, la resténose après angioplastie et la pose d'une endoprothèse, l'anévrisme de l'aorte abdominale, les inflammations, les maladies auto-immunes, la malaria, la cytopathie du tissu du fond oculaire et les maladies respiratoires.
Gabriel Tobias
Krauss Nancy Elisabeth
Mirzadegan Taraneh
Palmer Wylie Solang
Smith David Bernard
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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