Biphenyl derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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167/242, 167/245

C07D 493/04 (2006.01) A61K 31/365 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2010992

ABSTRACT The present invention is directed to a novel biphenyl derivative of the formula: Image wherein Ring A is a substituted or unsubstituted sulfur-containing or oxygen-containing heteromonocyclic ring; Ring B is a ring of the formula: Image or Image each of R1 to R3 is a hydrogen atom, a halogen atom or a lower alkoxy group, or R1 is a hydrogen atom, and R2 and R3 are combined together to form a lower alkylenedioxy group; R4 is a lower alkyl group which may have a substituent selected from a lower alkoxy group and a lower alkoxycarbonyl group; Y is a methylene group or a carbonyl group, and a pharmaceutically acceptable salt thereof. Said derivatives and pharmaceutically acceptable salts thereof are useful as a therapeutic or prophylactic agent for hepatic diseases.

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