A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/14 (2006.01)
Patent
CA 2596280
Methods and composition are described for low immunogenic protein, polypeptide or peptide formulations. The method comprises forming complexes of the protein, polypeptide or peptide with a binding agent which can be a serine containing compound or other phosphatidyl compounds or phospholipids. The complexes formed include simple complexes, micelles, cochleate structures, liposomes, non-bilayer and novel lipidic structures. The antigenicity and imminogenicity of the protein, polypeptides or peptides is reduced upon formation of such complexes.
L'invention porte sur une méthode et sur une composition permettant d'obtenir des préparations de protéines, polypeptides ou peptides de faible immunogénicité. Ladite méthode consiste à former des complexes de protéines, polypeptides ou peptides plus d'un agent liant, par exemple un composé contenant de la sérine, ou d'autres composés de phosphatidyle, ou des phospholipides. Les complexes formés comprennent: des complexes simples, des micelles, des structures de cochléats, des liposomes, des structures non bicouche, et de nouvelles structures lipidiques. L'antigénicité et l'immunogénicité des protéines, polypeptides ou peptides se trouvent réduites par la formation de tels complexes.
Balasubramanian Sathyamagalam
Purohit Vivek S.
Ramani Karthik
Straubinger Robert M.
Ridout & Maybee Llp
The Research Foundation Of State University Of New York
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