Piperidine derivatives as calcium channel antagonists

Details Piperidine derivatives as calcium channel antagonists Piperidine derivatives as calcium channel antagonists

C - Chemistry, Metallurgy

07

D

C07D 295/096 (2006.01) A61K 31/395 (2006.01) C07D 205/04 (2006.01) C07D 207/06 (2006.01) C07D 211/14 (2006.01) C07D 223/04 (2006.01) C07D 225/02 (2006.01) C07D 295/092 (2006.01) C07D 295/108 (2006.01)

Patent

CA 2152394

Compounds of formula (I): wherein R1 represents C1-6alkyl, halogen or phenyl; R2, represents hydrogen, C1-6alkyl halogen or phenyl; R3 represents hydroxyl or a group convertible thereto in vivo; R4 represents C1-6alkyl; p is zero, 1 or 2; X represents -CH2-, -C ? O, O or S; n is an integer from 4 to 10; m is an integer from 3 to 8; and salts thereof are useful as calcium antagonists, e.g. in the treatment of conditions relating to an accumulation of calcium in brain cells.

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