A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/215 (2006.01) A61K 31/12 (2006.01) A61K 31/192 (2006.01) A61K 31/222 (2006.01) A61K 31/4402 (2006.01)
Patent
CA 2415189
Compounds are described which modulate the tzrosine kinase activity of p56lck and signal transduction pathways in which this enzyme is involved. The invention also relates to compounds which have immunomodulatory activity, e.g., which have immunosuppressant or immunostimulatory activity, and/or which have an antineoplastic effect. The invention further relates to compositions comprising these compounds, and methods of using them.
L'invention concerne des composés modulant la tyrosine kinase de l'enzyme p56?lck¿ et les trajets de transduction des signaux sur lesquels intervient cette enzyme. L'invention concerne également des composés ayant une activité immunomodulatrice (par exemple, immunosuppression ou immunostimulation) et/ou un effet antinéoplasique. L'invention concerne enfin des compositions renfermant les composés en question et des procédés relatifs à leur utilisation.
Hayashi Jun
Mackerell Alexander D.
Johnson Ernest Peter
University Of Maryland Baltimore
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