Vascular endothelial growth factor 2

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 14/52 (2006.01) C07K 16/22 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2184584

Disclosed is a human VEGF2 polypeptide and DNA (RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and or prophylactic effects against various diseases. Also provided are methods of using the antibodies and antagonists to inhibit the action of VEGF2 for therapeutic purposes.

L'invention concerne un polypeptide du facteur 2 de croissance endothéliale vasculaire, et de l'ADN (ARN) codant pour ces polypeptides dudit facteur de croissance 2 endothéliale vasculaire. L'invention porte également sur un mode opératoire pour produire ledit polypeptide par des techniques de recombinaison et pour produire des anticorps et des antagonistes dirigés contre ledit polypeptide. Ces polypeptides peuvent être combinés avec un excipient ou un diluant pharmaceutique approprié pour produire des effets diagnostiques, thérapeutiques et/ou prophylactiques contre diverses maladies. Des procédés d'utilisation desdits anticorps et antagonistes pour inhiber l'action dudit facteur 2 de croissance endothéliale vasculaire à des fins thérapeutiques sont également décrits.

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