Type c lectins

Details Type c lectins Type c lectins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/16 (2006.01)

Patent

CA 2250381

The invention concerns members of the endocytic type C lectin family and methods and means for producing them. The native polypeptides of the invention are characterized by containing a signal sequence, a cysteine rich domain, a fibronectin type II domain, 8 type C lectin domains, a transmembrane domain and a cytoplasmic domain. Nucleotide sequences encoding such polypeptides, vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the type C lectins are also within the scope of the invention.

L'invention concerne de nouveaux membres de la famille des lectines endocytiques de type C et des procédés et moyens pour les produire. Les polypeptides natifs de l'invention ont ceci de particulier, qu'ils contiennent une séquence signal, un domaine riche en cystéine, un domaine de fibronectine de type II, 8 domaines de lectine de type C, un domaine transmembranaire et un domaine cytoplasmique. L'invention porte, également, sur des séquences nucléotidiques codant pour de tels polypeptides, des vecteurs contenant ces séquences nucléotidiques, des cellules hôtes de recombinaison transformées par ces vecteurs et des procédés de production par recombinaison des nouvelles lectines de type C.

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