Oral combinations of hydroxocobalamin and folic acid

Details Oral combinations of hydroxocobalamin and folic acid Oral combinations of hydroxocobalamin and folic acid

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2366899

A variety of conditions is known wherein vitamin B12 is deficient, or wherein the administration of vitamin B12 is beneficial. Classically, once detected and if appropriate, these have been treated by the parenteral administration of vitamin B12 as oral administration is believed to be ineffective. Available oral preparations of vitamin B12 all contain cyanocobalamin which is less desirable than hydroxocobalamin. In accordance with the invention, effective oral formulations are provided which include, in addition to the hydroxocobalamin, folic acid or other folate precursor. The formulation for oral administration should be such as to provide, for a given daily dose, 0.5 to 50 mg hydroxocobalamin and 0.5 to 50 mg folic acid.

On connaît diverses pathologies dans lesquelles il existe une carence en vitamine B¿12? ou bien dans lesquelles l'administration de vitamine B¿12? est bénéfique. Généralement, une fois ces pathologies décelées, elles sont, si nécessaire, traitées par administration parentérale de vitamine B¿12?, l'administration par voie orale étant considérée comme inefficace. Les préparations administrables par voie orale disponibles contiennent toutes de la cyanocobalamine alors qu'il serait préférable qu'elle continssent de l'hydroxocobalamine. Cette invention porte sur des formulations efficaces, administrables par voie orale, contenant, en sus de l'hydroxocobalamine, de l'acide folique ou un autre précurseur folate. La formulation pour administration orale est dosée pour fournir, pour une dose quotidienne donnée, de 0,5 à 50 mg d'hydroxocobalamine et de 0,5 à 50 mg d'acide folique.

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