A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 38/48 (2006.01) A61K 38/55 (2006.01)
Patent
CA 2298475
A method is provided for inhibiting or preventing toxicity and other unwanted effects (a) caused by solvents for pharmaceuticals which solvents or emulsifier which contain amphiphilic molecules such as polyethoxylated oils or a derivative thereof, or (b) caused by a drug in a vehicle containing amphiphilic molecules such as phospholipids or derivative thereof, employing a complement inhibitor. Drug compositions containing amphiphilic molecules, or derivatives thereof and a complement inhibitor, and pharmaceutical compositions including a drug, solvent or carrier containing amphiphilic molecules or derivatives thereof, and a complement inhibitor are also provided.
On décrit un procédé permettant d'inhiber ou de prévenir la toxicité et d'autres effets indésirables (a) provoqués par des solvants destinés à des substances pharmaceutiques, ces mêmes solvants ou un émulsifiant contenant des molécules amphiphiles telles que des huiles polyéthoxylées ou un dérivé de ces dernières, ou (b) provoqués par un médicament incorporé dans un excipient contenant des molécules amphiphiles telles que des phospholipides ou un dérivé de ces derniers; ce procédé comprenant l'utilisation d'un inhibiteur complémentaire. On décrit également des compositions de médicaments contenant des molécules amphiphiles ou des dérivés de ces dernières et un inhibiteur complémentaire, et des compositions pharmaceutiques contenant un médicament, un solvant ou un excipient contenant des molécules amphiphiles ou des dérivés de ces dernières ainsi qu'un inhibiteur complémentaire.
Alving Carl R.
Szebeni Janos
Fetherstonhaugh & Co.
Walter Reed Army Institute Of Research
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