Enhancement of transfection of dna into the liver

Details Enhancement of transfection of dna into the liver Enhancement of transfection of dna into the liver

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/00 (2006.01) A61K 31/7088 (2006.01) A61K 47/00 (2006.01) A61N 7/00 (2006.01) A61P 3/06 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2452471

A method for transfection of a DNA or RNA, such as the apo A1 gene into the liver to regulate lipid metabolism comprises injection of a solution containing the DNA or RNA gene into the liver using gas microbubbles or microspheres and using ultrasound to induce the expression of the gene in the liver

L'invention concerne un procédé de transfection d'ADN ou d'ARN, notamment celle du gène apo A1, dans le foie, pour réguler le métabolisme des lipides, consistant à injecter une solution contenant le gène d'ADN ou d'ARN dans le foie, en faisant appel à des microbulles, ou à des microsphères de gaz, et en faisant appel à des ultrasons pour induire l'expression du gène dans le foie.

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