Methods and compositions relating to cardiac-specific...

Details Methods and compositions relating to cardiac-specific... Methods and compositions relating to cardiac-specific...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12P 21/02 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2432278

The present invention relates to a novel cardiac-specific transcription factor, myocardin. This molecule modulates the development and differentiation of cardiomyocytes and is a potent inhibitor of cell growth. Methods to exploit these observations are provided and include respecifiying non-cardiac cells into cardiac cells, stimulating cardiac tissue regeneration, and methods for treating cardiomyopathies, myocardial infarction.

L'invention concerne un nouveau facteur de transcription spécifique du muscle cardiaque, le myocarde. Cette molécule module le développement et la différenciation des cardiomyocytes et constitue un inhibiteur puissant de la croissance cellulaire. Par ailleurs, l'invention concerne des méthodes d'exploitation de ces observations, lesquelles consistent à respécifier les cellules non cardiaques en cellules cardiaques et à stimuler la régénération des tissus cardiaques, ainsi que des méthodes de traitement des cardiomyopathies et de l'infarctus du myocarde.

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