Cell penetrating peptides for intracellular delivery of...

Details Cell penetrating peptides for intracellular delivery of... Cell penetrating peptides for intracellular delivery of...

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C07K 7/08 (2006.01) C12N 15/11 (2006.01) C12N 15/87 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2632451

The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9RALX9RX1LX2RSLX9X3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.

La présente invention concerne des peptides de pénétration cellulaire qui comprennent une séquence d'acides aminés GLX9RALX9RX1LX2RSLX9X3X4X5X6X7X8 (SEQ ID N° 1), dans laquelle X1 est A, L ou G, X2 est W ou absent, X3 est R ou K, X4 est K, L ou S, X5 est L ou K, X6 est R ou W, X7 est K ou S, X8 est A, V ou Q, et X9 est W, F ou Y. Ces PPC peuvent être utilisés comme vecteurs pour la délivrance d'acides nucléiques et/ou de protéines et/ou de peptides aux cellules in vitro ou in vivo.

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