A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/30 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/48 (2006.01)
Patent
CA 2699290
Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an IGFBP7 agent if the tumor has increased Ras-BRAF-MEK-Erk signaling, is dependent for growth and/or survival upon the Ras-BRAF-MEK-Erk signaling pathway, and/or expresses an activated or oncogenic BRAF or RAS.
L'invention concerne des procédés de traitement d'une tumeur chez un sujet comprenant l'identification d'un sujet présentant, risquant de présenter ou susceptible de présenter une tumeur, et l'administration au sujet d'une quantité efficace d'un agent IGFBP7 si la tumeur présente une signalisation accrue de Ras-BRAF-MEK-Erk, si elle dépend de la voie de signalisation Ras-BRAF-MEK-Erk pour sa croissance et/ou sa survie et/ou si elle exprime un BRAF ou un RAS activé ou oncogène.
Green Michael
Wajapeyee Narendra
Smart & Biggar
University Of Massachusetts
LandOfFree
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