Methods and use of inducing apoptosis in cancer cells

Details Methods and use of inducing apoptosis in cancer cells Methods and use of inducing apoptosis in cancer cells

A - Human Necessities

61

K

A61K 31/122 (2006.01) A61K 9/127 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2721071

The present disclosure relates to a method of inducing apoptosis in a cancer cell by delivery of exogenous Coenzyme Q1O or its metabolites thereof in a pharmaceutically acceptable carrier to effectuate cell contact of endogenous Coenzyme Q1O or its metabolites thereof in addition to but not limited to mevalonic acid and oleic acid to form an intracellular complex. The present disclosure also provides a method of modulating the p53 pathway and Bcl-2 protein family in a manner that restores the apoptotic potential to a cancer cell by delivery of Coenzyme Q1O in a pharmaceutically acceptable carrier. The present disclosure further provides a method to specifically normalize the ratio of pro-apoptotic and anti-apoptotic members of the Bcl-2 gene family in a proportion to re-program a cancer cell to undergo apoptosis.

L'invention concerne un procédé consistant à induire l'apoptose d'une cellule cancéreuse par fourniture d'un coenzyme exogène Q10 ou de ses métabolites dans un support pharmaceutiquement acceptable pour effectuer un contact cellulaire de coenzyme endogène Q10 ou de ses métabolites en plus, mais sans être limité à ceci, de l'acide mévalonique et de l'acide oléique pour former un complexe intracellulaire. La présente description fournit aussi un procédé de modulation de la voie de p53 et de la famille de protéine Bcl-2 d'une manière qui restaure le potentiel apoptotique d'une cellule cancéreuse par fourniture de coenzyme Q10 dans un support pharmaceutiquement acceptable. La présente description fournit en outre un procédé pour normaliser spécifiquement le rapport d'éléments pro-apoptotique et anti-apoptotique de la famille du gène Bcl-2 dans une proportion pour reprogrammer une cellule cancéreuse pour qu'elle subisse une apoptose.

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