Thrombomodulin (thbd) haplotypes predict outcome of patients

Details Thrombomodulin (thbd) haplotypes predict outcome of patients Thrombomodulin (thbd) haplotypes predict outcome of patients

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2558510

The invention provides methods and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition. The method generally comprises determining a thrombomodulin genotype(s) of a subject for one or more SNPs, comparing the determined genotype with known genotypes for the polymorphism that correspond with the ability of the subject to recover from the inflammatory condition and identifying subjects based on their prognosis.

L'invention concerne des méthodes et des trousses permettant d'établir un pronostic pour un patient atteint d'une affection inflammatoire ou présentant un risque de développer une affection inflammatoire. Cette méthode consiste globalement à déterminer un ou plusieurs génotypes de la thrombomoduline chez un sujet pour un ou plusieurs polymorphismes nucléotidiques simples, à comparer le génotype déterminé à des génotypes connus pour les polymorphismes correspondant aux chances de récupérer d'un patient atteint d'une affection inflammatoire et à identifier des sujets sur la base de leur pronostic.

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