Processes for the preparation of docetaxel

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 305/14 (2006.01)

Patent

CA 2610898

The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10 protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.

Procédés pour l'élaboration de docétaxel, produit par protection des groupes hydroxy C(7) et C(10) de 10DAB avec un groupe de protection en pontage à base de silicium. Le dérivé 10-DAB à protection 7,10 résultant est ensuite dérivatisé et déprotégé, donnant le docétaxel.

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