C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 9/00 (2006.01) C12N 11/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2110799
2110799 9222324 PCTABS00018 Recombinant DNA methods are described for the production of antibody F(ab')2 and Fab' fragment molecules from transformed microorganisms such as bacteria and yeast. The recombinant F(ab')2 and Fab' fragments are secreted from the host cells and may be recovered directly from the fermentation culture. These direct methods of F(ab')2 and Fab' production are advantageous over existing art methods by avoiding proteolytic digestions and obtaining homogeneous molecules. Methods are described for the conjugation of these fragments, by methods targeting either available lysine amino acid residues or selectively-reducible cysteine residues, to active moieties such as ricin toxin A chain. The microbially-produced F(ab')2 and Fab' fragment molecules and their immunoconjugates have a wide variety of therapeutic and diagnostic uses.
Better Marc D.
Carroll Steve
Horwitz Arnold H.
Gowling Lafleur Henderson Llp
Xoma Corporation
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