Eukaryotic peptide uptake system for transportation of...

Details Eukaryotic peptide uptake system for transportation of... Eukaryotic peptide uptake system for transportation of...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01H 5/00 (2006.01) A01N 33/00 (2006.01) A01N 37/46 (2006.01) C07K 14/395 (2006.01) C07K 14/70 (2006.01) C07K 14/705 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2364584

An oligopeptide transporter in the yeast Saccharomyces cerevisiae mediates the uptake of tetra- and pentapeptides, including the endogenous opioids leucine enkephalin (Tyr-Gly-Gly-Phe-Leu) and methionine enkephalin (Tyr-Gly-Gly-Phe- Met). The transporter is encoded by the gene OPT1. The system is specific for tetra- and pentapeptides and can be inhibited by the opioid receptor antagonists naloxone and naltrexone. Vectors allowing expression of OPT1 and methods of use are disclosed. Treatment of OPT1p with toxic enkephalins as an antifungal method is also disclosed.

L'invention concerne un transporteur oligopeptidique, présent dans la levure Saccharomyces cerevisiae, et qui induit la capture de tétra- et pentapeptides, notamment les opioïdes endogènes que sont la leucine-enképhaline (Tyr-Gly-Gly-Phe-Leu) et la méthionine-enképhaline (Tyr-Gly-Gly-Phe-Met). Ce transporteur est codé par le gène OPT1. Ce système est spécifique des tétra- et pentapeptides et il peut être inhibé par les antagonistes du récepteur opioïde, la naloxone et la naltrexone. L'invention concerne également des vecteurs permettant l'expression de OPT1 ainsi que des procédés d'utilisation. Elle concerne encore le traitement de OPT1p à l'aide d'enképhalines toxiques, en tant que procédé antifongique.

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