Inhibition of dna modulation caused by mutated p53

Details Inhibition of dna modulation caused by mutated p53 Inhibition of dna modulation caused by mutated p53

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2318313

The invention relates to a method for inhibiting DNA modulation caused by mut p53, comprising the inhibition of mut p53 bonding on the DNA with strand separating potential. The invention also relates to a system for identifying substances suitable for said inhibition.

La présente invention concerne un procédé permettant d'inhiber la modulation d'ADN due à la protéine p53, lequel comprend l'opération consistant à inhiber la liaison de la protéine p53 mutante à l'ADN présentant un potentiel de séparation des brins. L'invention concerne en outre un système permettant l'identification de substances convenant pour une telle inhibition.

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