A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4439 (2006.01) A61K 31/165 (2006.01) A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2528395
There is disclosed the combination of a growth hormone secretagogue and at least one agent which modifies the production or processing of A.beta. in the brain, said at least one agent being selected from: (a) compounds which inhibit the secretion of A.beta.; (b) compounds which selectively inhibit the secretion of the 1-42 isoform of A.beta.; (c) compounds which inhibit the aggregation of A.beta.; and (d) antibodies which selectively bind to A.beta.; for use in treatment or prevention of a disease associated with deposition of A.beta. in the brain.
La présente invention concerne une combinaison d'un secretagogue d'hormone de croissance et d'au moins un agent qui modifie la production ou le traitement de A.szlig. dans le cerveau. Cet agent est choisi parmi (a) des composés qui inhibent la sécrétion de A.szlig., (b) des composés qui inhibent de manière sélective la sécrétion de l'isoforme 1-42 de A.szlig., (c) des composés qui inhibent l'agrégation de A.szlig. et (d) des anticorps qui se lient de manière sélective à A.szlig.. Ladite combinaison est utilisée pour traiter ou prévenir une maladie associée au dépôt de A.szlig. dans le cerveau.
Merck Sharp & Dohme Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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