Chromans and thiochromans with retinoid-like activity

C - Chemistry – Metallurgy – 07 – D

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C07D 335/06 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) C07D 311/14 (2006.01) C07D 311/16 (2006.01) C07D 311/58 (2006.01)

Patent

CA 2092178

2092178 9206084 PCTABS00011 Retinoid-like activity is exhibited by compounds of formula (I), where X is S, O; R1, R2 and R3 are hydrogen or lower alkyl; R4 and R5 are hydrogen or lower alkyl with the proviso that R4 and R5 cannot both be hydrogen, R6 is hydrogen, lower alkyl, lower alkenyl, lower cycloalkyl or halogen; n is 0 - 5, and B is H, -COOH or a pharmaceutically acceptable salt, ester or amide thereof, -CH2OH or an ether or ester derivative, or -CHO or an acetal derivative, or -COR1 or a ketal derivative where R1 is -(CH2)mCH3 where m is 0-4, or a pharmaceutically acceptable salt thereof.

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