Pyridazinyl- piperazines and their use as histamine h3...

Details Pyridazinyl- piperazines and their use as histamine h3... Pyridazinyl- piperazines and their use as histamine h3...

C - Chemistry, Metallurgy

07

D

C07D 237/20 (2006.01) A61K 31/501 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2532236

The present invention relates to piperazines of formula I. The compounds show a high and selective binding affinity for the histamine H3 receptor, indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. As a result, the compounds are useful for the treatment of diseases or disorders related to the histamine H3 receptor.

L'invention concerne se rapporte aux pipérazines représentées par la formule I. Ces composés présentent une affinité de liaison élevée et sélective pour le récepteur histaminique H3, indiquant une activité antagoniste, agoniste inverse ou agoniste envers le récepteur histaminique H3. Ils conviennent par conséquent pour le traitement des maladies ou des troubles liés au récepteur histaminique H3. (formule I)

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