Immunogenic chimeras comprising nucleic acid sequences...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) C07K 14/075 (2006.01) C07K 14/145 (2006.01) C07K 14/47 (2006.01) C07K 14/77 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2158455

Immumogenic chimeric proteins comprising an end endoplasmic reticulum signal sequence and at least one other peptide are disclosed. The invention relates to the design of vaccinia virus constructs capable of directing host organism synthesis of immunogenic chitneric proteins which can be used as as immunogens, as vaccines, or in methods of treatment for cancer, infectious disease; autoimmune diseases. .r~ .. s, as vaccines, or in methods of treatment for cancer, infectious diseasesj or ~ diseases.

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