C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/58 (2006.01) A61K 38/49 (2006.01) A61P 7/02 (2006.01) C12N 9/50 (2006.01) C12N 15/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/56 (2006.01) G01N 33/573 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2271697
Variants of tissue plasminogen factor exhibit significantly enhanced fibrin stimulation, dramatically increased discrimination among fibrin co-factors, marked resistance to inhibition by PAI-1, and substantially increased zymogenicity, a combination of properties that enhance the therapeutic utility of the enzyme.
La présente invention concerne des variantes du facteur plasminogène tissulaire qui font preuve d'une amélioration notable de la stimulation de la fibrine, d'une discrimination considérablement accrue entre cofacteurs de la fibrine, d'une résistance marquée à l'inhibition par PAI-1, et d'une zymogénicité sensiblement accrue, une combinaison de propriétés qui renforcent l'utilité thérapeutique de l'enzyme.
Mbm Intellectual Property Law Llp
The Scripps Research Institute
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