Process for preparing an inter-alpha-trypsine inhibitor...

Details Process for preparing an inter-alpha-trypsine inhibitor... Process for preparing an inter-alpha-trypsine inhibitor...

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 38/57 (2006.01) C07K 1/36 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2174231

The invention relates to a process for preparing ITI from human plasma, comprising two chromatography steps on anion exchanger gels and an affinity chromatography step on immobilized heparin. The process also comprises a viral inactivation treatment. The ITI concentrate thus obtained is of a quality suitable for therapeutical use.

L'invention concerne un procédé de préparation d'ITI à partir de plasma humain qui comporte deux étapes chromatographie sur gels échangeurs d'anions puis une étape de chromatographie d'affinité sur héparine. Le procédé comprend également un traitement d'inactivation virale. Le concentré d'ITI obtenu est d'une qualité adaptée à un usage thérapeutique.

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