C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/39 (2006.01) A61K 47/48 (2006.01) C12N 1/38 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2173731
Neuron-glia cell adhesion molecule (Ng-CAM), alone or in combination with one or more additional agents, is useful in promoting the regeneration of a nerve in a subject having peripheral or spinal nerve damage. Pharmaceutical compositions comprising Ng-CAM are disclosed. Also provided are methods for diagnosing a neuronal disorder associated with abnormal levels of Ng-CAM and methods for assaying a test agent for its ability to enhance or inhibit the activity of Ng-CAM in promoting nerve regeneration.
Cette invention concerne une molécule d'adhérence intercellulaire neurone-glie (Ng-CAM) qui est utile, employée seule ou avec un ou plusieurs agents supplémentaires, pour activer la régénération d'un nerf chez un sujet souffrant de lésions des nerfs périphériques ou rachidiens. Des compositions pharmaceutiques comprenant cette molécule Ng-CAM sont décrites ainsi que des procédés de diagnostic d'un dérèglement neuronal associé à des taux anormaux de Ng-CAM et des procédés de dosage d'un agent de test capable d'augmenter ou d'inhiber l'activité de ladite molécule Ng-CAM pour activer la régénération nerveuse.
Fetherstonhaugh & Co.
New York University
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