Optimisation of synthetic catalysts by means of directed...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/10 (2006.01) C12N 15/52 (2006.01)

Patent

CA 2451062

The invention relates to a method for producing optimised catalysts which are optimised, during the course of said production method, in terms of a desired catalyst property or a plurality of properties. A synthetic metalliferous or metal-free catalyst is chemically linked to enzyme or protein mutants which are produced by means of molecular biology, and the catalysts created thereby are subjected to an optimisation process using methods from molecular biology, or the directed evolution of enzymes. The invention also relates to the catalysts which can be obtained by said method.

La présente invention concerne un procédé permettant de produire des catalyseurs optimalisés qui, au cours du procédé de production, sont optimalisés pour ce qui est d'une caractéristique de catalyse recherchée ou plusieurs propriétés. Selon ce procédé, un catalyseur de synthèse métallifère ou dépourvu de métal est lié chimiquement à des mutants enzymatiques ou protéiques issus de la biologie moléculaire, et les catalyseurs résultants sont ensuite optimalisés au cours d'un processus faisant appel à des méthodes de biologie moléculaire, c'est-à-dire, d'évolution dirigée d'enzymes. L'invention se rapporte en outre aux catalyseurs que ledit procédé permet de produire.

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