C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/08 (2006.01) A61K 31/407 (2006.01) A61P 25/00 (2006.01) C07C 233/77 (2006.01) C07D 207/14 (2006.01)
Patent
CA 2758367
The inventions relates to the compounds of formula (I) where: R is a hydrogen atom or a group selected from the (C1d- C6)alkyl and (C3-C7)-cycloalkyl groups, optionally substituted by one or more groups independently selected from a fluorine atom, the (C3-C7)-cycloalkyl, (C2-C4)alkenyl, phenyl, (C1-C6)alkoxy, and hydroxy groups; the phenyl group being optionally substituted by one or more (C1-C6)alkoxy groups; R1 is a phenyl group optionally substituted by one or more substituants independently selected from halogen atoms, the (C1-C6)alkyl, (C1-C6)alkoxy, halo-(C1C6)alkyl, hydroxy, halo-(C1-C6)alkoxy, (C1-C6)alkyl-thio, and (C1-C6)alkyl-SO2 groups; R2 is one or more substituants selected from hydrogen atoms, halogen atoms, the halo-(C1-C6)alkyl, (C1-C6)alkyl, (C3-C7)cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)alkyl, (C1C6)alkoxy, (C1C6)alkyl-thio, and (C1-C6)alkyl-SO2 groups; in the form of a base or an addition salt to an acid. The invention further relates to the use thereof in therapy and to a method for synthesizing same.
Composés de formule (I) : dans laquelle : - R représente un atome d'hydrogène ou un groupe choisi parmi les groupes (C 1d-C6)alkyle, (C3-C7)-cycloalkyle, éventuellement substitué par un ou plusieurs groupes choisis indépendamment l'un de l'autre parmi l'atome de fluor, les groupes (C3-C7)- cycloalkyle, (C2-C4)alcényle, phényle, (C1-C6)alcoxy, hydroxy; le groupe phényle est éventuellement substitué par un ou plusieurs groupes (C1-C6)alcoxy; - R1 représente un groupe phényle éventuellement substitué par un ou plusieurs substituants choisis indépendamment l'un de l'autre parmi les atomes d'halogène, les groupes (C1-C6)alkyle, (C1-C6)alcoxy, halo-(C1C6)alkyle, hydroxy, halo-(C1- C6)alcoxy, (C1C6)alkyle- thio, (C1-C6)alkyle-SO2, - R2 représente un ou plusieurs substituants choisis parmi l'atome d'hydrogène, les atomes d'halogène, les groupes halo -(C1C6)alkyle, (C1-C6)alkyle, (C3-C7)cycloalkyle, (C3-C7)-cycloalkyl-(C1-C3)alkyle, (C1C6)alcoxy, (C1C6)alkyl-thio, (C1C6)alkyle-SO2; à l'état de base ou de sel d'addition à un acide. Utilisation en thérapeutique et procédé de synthèse.
Dargazanli Gihad
Estenne-Bouhtou Genevieve
Robic
Sanofi
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