Use of a melanoma differentiation associated gene (mda-7)...

A - Human Necessities – 61 – K

Patent

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Details

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2263750

This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under conditions that permit the expression of the gene so as to thereby reverse the cancerous phenotype of the cell. This invention also provides a method for reversing the cancerous phenotype of a cancer cell by introducing the gene product of the above-described gene into the cancerous cell so as to thereby reverse the cancerous phenotype of the cell. This invention also provides a pharmaceutical composition having an amount of a nucleic acid having the melanoma differentiation associated gene (mda-7) or the gene product of a melanoma differentiation associated gene (mda-7) effective to reverse the cancerous phenotype of a cancer cell and a pharmaceutically acceptable carrier.

Cette invention concerne un procédé d'inversion du phénotype cancéreux d'une cellule cancéreuse qui consiste à introduire un acide nucléique comportant le gène associé à la différentiation des mélanomes (mda-7) à l'intérieur de la cellule dans des conditions qui permettent l'expression du gène en vue de l'inversion du phénotype cancéreux de la cellule. Cette invention concerne également un procédé d'inversion du phénotype cancéreux d'une cellule cancéreuse qui consiste à introduire le produit génique du gène décrit ci-dessus à l'intérieur de la cellule cancéreuse de façon à inverser le phénotype cancéreux de la cellule. Cette invention concerne également une composition pharmaceutique comportant un acide nucléique contenant le gène associé à la différentiation des mélanomes (mda-7) ou le produit génique d'un gène associé à la différentiation des mélanomes (mda-7), en quantité suffisante pour inverser le phénotype cancéreux d'une cellule cancéreuse, ainsi qu'un excipient pharmaceutiquement acceptable.

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