Prevention and treatment of breast cancer with 4-hydroxy...

Details Prevention and treatment of breast cancer with 4-hydroxy... Prevention and treatment of breast cancer with 4-hydroxy...

A - Human Necessities

61

K

A61K 31/138 (2006.01) A61K 47/14 (2006.01) A61K 47/38 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2519980

The present invention provides methods for treating and preventing breast cancer by administering 4-hydroxy tamoxifen to a patient. It also provides pharmaceutical compositions of 4-hydroxy tamoxifen suitable for percutanous administration. When percutaneously administered to a patient's breasts, 4- hydroxy tamoxifen concentrates locally, and exerts an anti-estrogenic effect. In patients with breast cancer, this effect reduces tumor tissue proliferation. In patients at risk for developing breast cancer, the anti- estrogenic effect prevents breast tumor formation.

L'invention concerne des méthodes de traitement et de prévention du cancer du sein, par administration de 4-hydroxy tamoxifène à des patientes. L'invention concerne également des compositions pharmaceutiques de 4-hydroxy tamoxifène adaptées à une administration par voie cutanée. Lorsque le 4-hydroxy tamoxifène est administré par voie cutanée à une patiente, au niveau des seins, le 4-hydoxy tamoxifène se concentre localement et exerce un effet anti-oestrogène. Chez les patientes souffrant de cancer du sein, cet effet réduit la prolifération du tissu tumoral. Chez des patientes exposées au risque de développer un cancer du sein, l'effet anti-oestrogène prévient la formation de tumeurs du sein.

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