Monoclonal antibody to novel antigen associated with human...

Details Monoclonal antibody to novel antigen associated with human... Monoclonal antibody to novel antigen associated with human...

C - Chemistry, Metallurgy

12

N

530/13, 167/130,

C12N 5/18 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2010253

ABSTRACT The present invention is concerned with a novel monoclonal antibody which binds strongly to a protein antigen associated with human tumors, including carcinomas of the colon, breast, ovary and lung, as well as melanomas and sarcomas. The antibody binds to normal human cells to a much lesser degree than to tumor cells. The antibody finds use both in diagnostic methods such as the detection of malignant cells associated with tumors and in therapeutic methods for treatment of humans with tumors. Also disclosed is a novel 100,000 dalton glycoprotein antigen found on the cell surface of human tumor cells. The amino terminal amino acid sequence of this antigen is: 1 5 10 15 20 25 W-Y-T-V-N-S-A-Y-G-D-T-I-I-I-P-X-R-L-D-V-P-Q-N-L-M-F in which X represents an unidentified amino acid.

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