G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) A61K 49/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2445202
This invention provides a method for evaluating efficacy of treatment of animals and humans using compositions comprising bacterial DNA and bacterial DNA preserved and complexed on bacterial cell walls. Biological markers such as cytokines, soluble FAS ligand (sFasL) and apoptosis markers released from cells following treatment are measured to assess efficacy of treatment and to identify non-responding patients. This method facilitates identification of animals and humans who should and who should not receive therapeutic administration of these bacterial compositions, and provide a means to evaluate efficacy of such treatment.
L'invention concerne une méthode destinée à évaluer l'efficacité d'un traitement d'animaux et d'humains au moyen de compositions comprenant de l'ADN bactérien et de l'ADN bactérien préservé et complexé sur des parois cellulaires bactériennes. Des marqueurs biologiques, tels que des cytokines, un ligand Fas soluble (sFasL) et des marqueurs d'apoptose libérés à partir de cellules après un traitement, sont mesurés en vue d'évaluer l'efficacité d'un traitement et d'identifier des patients réfractaires. Cette méthode facilite l'identification d'animaux et d'humains nécessitant ou ne nécessitant pas une administration thérapeutique de ces compositions bactériennes, et fournit un moyen d'évaluer l'efficacité d'un tel traitement.
Filion Mario C.
Phillips Nigel C.
Bereskin & Parr
Bioniche Life Sciences Inc.
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