Nucleic acid and corresponding protein entitled 161p5c5...

Details Nucleic acid and corresponding protein entitled 161p5c5... Nucleic acid and corresponding protein entitled 161p5c5...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 35/14 (2006.01) A61K 38/00 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 51/00 (2006.01) A61M 36/14 (2006.01) A61P 35/00 (2006.01) C07H 21/04 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 16/

Patent

CA 2440461

A novel gene (designated 161P5C5) and its encoded protein, and variants thereof, are described wherein 161P5C5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P5C5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P5C5 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P5C5 can be used in active or passive immunization.

L'invention concerne un nouveau gène (désigné par 161P5C5) et sa protéine codée et des variants de celui-ci, où 161P5C5 présente une expression spécifique d'un tissu dans les tissus normaux d'adulte, et est exprimé de façon aberrante dans les cancers spécifiés au tableau 1. En conséquence, 161P5C5 fournit un diagnostic, un pronostic, et une cible prophylactique et/ou thérapeutique pour le cancer. Le gène 161P5C5 ou un fragment de celui-ci, ou sa protéine codée, ou des variants de celle-ci, ou un fragment de celle-ci, peuvent être utilisés pour déclencher une réponse immunitaire humorale ou cellulaire ; des anticorps ou des cellules T réagissant avec 161P5C5 peuvent être utilisés dans une immunisation active ou passive.

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