C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) C12N 5/0783 (2010.01) C12N 5/0784 (2010.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2752560
The present invention provides isolated peptides having the amino acid sequence of SEQ ID NO: 34 or fragments thereof, which bind to HLA antigen and induce cytotoxic T lymphocyte (CTL). The present invention further provides peptides which include one, two, or several amino acid insertions, substitution or addition to the aforementioned peptides or fragments, but still have the cytotoxic T cell inducibility. Further provided are nucleic acids encoding any of these aforementioned peptides as well as pharmaceutical substances or compositions including any of the aforementioned peptides or nucleic acids. The peptides, nucleic acids, pharmaceutical substances or compositions of the present invention may be used for treating cancer or tumor.
La présente invention concerne des peptides isolés ayant la séquence d'acides aminés de SEQ ID NO: 34 ou des fragments de ceux-ci, qui se lient à l'antigène HLA et induisent des lymphocytes T cytotoxiques (CTL). La présente invention concerne en outre des peptides qui comprennent une, deux, ou plusieurs insertions, substitutions ou additions d'acide aminé aux peptides ou fragments mentionnés ci-dessus, mais ont encore le pouvoir inducteur de lymphocytes T cytotoxiques. La présente invention concerne en outre des acides nucléiques codant pour l'un quelconque de ces peptides mentionnés ci-dessus ainsi que des substances ou compositions pharmaceutiques comprenant l'un quelconque des peptides ou acides nucléiques mentionnés ci-dessus. Les peptides, acides nucléiques, substances ou compositions pharmaceutiques de la présente invention peuvent être utilisés pour traiter un cancer ou une tumeur.
Ohsawa Ryuji
Tsunoda Takuya
Watanabe Tomohisa
Yoshimura Sachiko
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Oncotherapy Science Inc.
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