Stable extended release oral dosage composition comprising...

A - Human Necessities – 61 – K

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A61K 31/4545 (2006.01) A61K 9/24 (2006.01) A61K 31/137 (2006.01) A61K 31/445 (2006.01) A61P 11/02 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2329217

A film-coated extended release solid oral dosage composition containing a nasal decongestant, pseudoephedrine or salt thereof, e.g., pseudoephedrine sulfate in a core effective to provide a geometric maximum plasma concentration of pseudoephedrine of about 345 ng/mL to about 365 ng/mL at a time of about 7.60 hrs to about 8.40 hrs and having two or three film-coatings on thecore, the second one containing an amount of the non-sedating antihistamine, desloratadine, effective to provide a geometric maximum plasma concentration of desloratadine of about 2.15 ng/mL to about 2.45 ng/mL at a time of about 4.0 hours to about 4.5 hours, and use of the composition for treating patients showing the signs and symptoms associated with allergic and/or inflammatory conditions of the skin and airway passages are disclosed.

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