A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) A61P 7/02 (2006.01)
Patent
CA 2462512
The field of the invention relates to percutaneous interventions of occluded arteries using local infusion of collagenase or a combination of enzymes that include collagenase. A method of is provided for treating chronically occluded animal tubes and cavities by administering a therapeutic effective amount of a proteolytic enzyme-containing formulation adjacent to an occluding atherosclerotic plaque, waiting for a pre-angioplasty waiting period, followed by crossing the plaque with an angioplasty guide wire. An in-vivo animal model of developing a chronic arterial occlusions is provided having the steps of isolating a segment of an animal artery, stopping blood flow with occlusive ligatures in the isolated arterial segment of the animal artery, injecting topical thrombin into the isolated arterial segment to form an acute thrombotic occlusion, and waiting while the acute thrombotic occlusion is converted into a chronic fibrotic occlusion.
L'invention concerne des interventions percutan~es r~alis~es sur des artres occluses par perfusion locale de collag~nase ou d'une combinaison d'enzymes qui comprennent de la collag~nase. L'invention concerne un proc~d~ de traitement de tubes et de cavit~s occlus chroniquement chez des animaux, ledit proc~d~ consistant ~ administrer une quantit~ th~rapeutique efficace d'une formulation contenant une enzyme prot~olytique adjacente ~ une plaque d'ath~roscl~rose d'occlusion, ~ attendre une p~riode de pr~-angioplastie, puis ~ proc~der au croisement de ladite plaque avec un fil-guide d'angioplastie. L'invention concerne un modle animal in vivo de d~veloppement d'occlusions art~rielles chroniques pr~sentant les ~tapes suivantes : isoler un segment d'une artre animale, stopper le flux sanguin au moyen de ligatures d'occlusion dans le segment art~riel isol~ de l'artre animale, injecter de la thrombine topique ~ l'int~rieur du segment art~riel isol~ pour former une occlusion thrombotique aigu~, et attendre que l'occlusion thrombotique aigu~ soit convertie en occlusion thrombotique chronique.
Strauss Bradley H.
Torys Llp
LandOfFree
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