Process for producing biologically active polymer...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 9/51 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2269444

A process is disclosed for producing biologically active polymer nanoparticle- nucleic acid conjugates by polymerising vinyl monomers with a low water solubility in an aqueous solution, then reacting the resulting polymer suspensions with the nucleic acids. The process is characterised in that the vinyl monomers are emulsion polymerised in the presence of cationic radical starters but in the absence of any emulsifier. The thus obtained polymer nanoparticle-nucleic acid conjugates are sufficiently stable in biological media and are characterised by a high transport efficiency through cellular membranes.

Selon ce procédé de production de conjugués biologiquement actifs d'acides nucléiques et de nanoparticules polymères, on polymérise des monomères de vinyle à faible solubilité dans l'eau dans une solution aqueuse, puis on réagit les suspensions de polymères ainsi obtenues avec les acides nucléiques. Le procédé décrit se caractérise en ce que l'on polymérise par émulsion les monomères de vinyle en présence de radicaux initiateurs cationiques mais en l'absence d'émulsifiants. Les conjugués d'acides nucléiques et de nanoparticules polymères ainsi produits ont une stabilité suffisante dans des milieux biologiques et se caractérisent par une haute efficacité de transport à travers les membranes cellulaires.

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