Triazolo-pyridazine derivatives as ligands for gaba receptors

Details Triazolo-pyridazine derivatives as ligands for gaba receptors Triazolo-pyridazine derivatives as ligands for gaba receptors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/41 (2006.01) A61K 31/50 (2006.01) C07D 237/00 (2006.01) C07D 249/00 (2006.01)

Patent

CA 2318952

A class of substituted 1,2,4-triazolo[4,3-b]pyridazine derivatives of formula (I), wherein Z represents cyclobutyl or pyrrolidin-1-yl, are selective ligands for GABAA receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.

L'invention porte sur une classe de dérivés 1,2,4-triazolo[4,3-b]pyridazine substitués de la formule (I) dans laquelle Z représente cyclobutyl ou pyrrolidin-1-yl. Ces dérivés ont des ligands sélectifs des récepteurs GABA¿A?, et ont notamment une haute affinité pour la sous-unité .alpha.2 et/ou .alpha.3 de ces récepteurs. En conséquence, ils présentent un avantage dans le traitement et/ou la prévention des troubles du système nerveux central tels que l'anxiété et les convulsions.

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