Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine...

Details Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine... Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine...

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/4353 (2006.01) A61P 29/02 (2006.01)

Patent

CA 2603493

The invention relates to substituted 4, 5, 6, 7-tetrahydro-isoxazolo [4, 5-c] pyridine compounds of formula (I), to a method for their production, to medicaments containing said compounds and to the use of said compounds for producing medicaments. It has been found that substituted 4,5,6,7-tetrahydro- isoxazolo[4,5-c] pyridine compounds of general formula (I) are suitable for noradrenaline receptor regulation, in particular for inhibiting the noradrenaline (NA) uptake, for 5-HT receptor regulation, in particular for inhibiting the 5-hydroxy-tryptophan (5-HT) uptake and/or for batrachotoxin (BTX) receptor regulation and can thus be used in particular as pharmaceutical active ingredients in medicaments for the prophylaxis and/or treatment of disorders or diseased that are associated with said receptors or processes.

L'invention concerne des composés 4,5,6,7-tétrahydro-isoxazolo[4,5-c]pyridine substitués de formule (I), des procédés pour leur production, des médicaments les contenant, ainsi que leur utilisation pour produire des médicaments. On a découvert que ces composés conviennent à la régulation des récepteurs de la noradrénaline, notamment à l'inhibition de la recapture de la noradrénaline, à la régulation des récepteurs 5-HT, notamment à l'inhibition de la recapture du 5-hydroxytryptophane, et/ou à la régulation des récepteurs de la batrachotoxine (BTX). Ainsi, ces composés peuvent donc particulièrement être utilisés en tant que principes actifs pharmaceutiques dans des médicaments servant à prévenir et/ou à traiter des troubles ou des maladies liés à ces récepteurs ou ces processus.

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