Cell culture improvements

Details Cell culture improvements Cell culture improvements

C - Chemistry, Metallurgy

12

N

C12N 5/02 (2006.01) C12N 5/00 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C07K 14/525 (2006.01) C07K 14/54 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2663442

The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.

L'invention concerne des procédés et des compositions perfectionnés pour produire une protéine recombinante, par exemple, un anticorps, dans une culture de cellules de mammifères. De plus, l'invention concerne des milieux de culture cellulaire améliorés, comprenant des milieux de production améliorés, des solutions d'alimentation et des alimentations de combinaison, qui peuvent être utilisés pour améliorer la productivité des protéines dans une culture cellulaire de mammifère.

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